A device to which an implantable lead is coupled may be configured to perform one or more impedance measurements subsequent to a sensed physiological event to determine whether the sensed physiological event is possibly associated with noise induced by an interfering signal. Interfering signals, such as electromagnetic fields generated by an external source, may induce voltages or currents on conductors of the implantable lead, which will have an effect on lead impedance measurements. By measuring one or more impedances associated with the lead during a time window that substantially coincides with the sensed physiological event, the device may determine whether the sensed events may have resulted from interference. The device may determine whether to further adjust operation of the IMD based on the classification of the sensed physiological event and a classification of one or more previously sensed physiological events.