PROCÉDÉ DE RUPTURE DE BIOFILMS BACTÉRIENS ET DE PRÉVENTION DE LA FORMATION DE BIOFILM BACTÉRIEN AU MOYEN D'UN COMPLEXE DE PEPTIDES ANTIMICROBIENS D'INSECTES
GORDYA, Nataliya Aleksandrovna,YAKOVLEV, Andrej Yur'evich,YAKOVLEV, Andrej Yurevich
申请号：
RURU2018/000346
公开号：
WO2018/226119A1
申请日:
2018.05.29
申请国别(地区):
RU
年份:
2018
代理人:
摘要：
The present invention relates to the fields of medicine, hygiene, cosmetology and veterinary and could be used for preventing bacterial biofilm formation and disrupting biofilms formed by pathogenic and opportunistic bacteria of various kinds at a skin and other surfaces of organism, surfaces of implants and medical instruments. Preferred application field of the invention is a prevention of forming biofilms resistant to antibiotic and antiseptic action, and a disruption of those biofilms. The invention is based on treating the infected surface with a specimen comprising a complex of antimicrobial peptides of Calliphora vicina (Diptera, Calliphoridae) or other species of synanthropic saprophages from the order Diptera, particularly, C. vomitoria, Lucilia sericata, Musca domestica, Hermetia illucense, in combination with an antibiotic or antiseptic. The antibiotic or antiseptic used for that end is selected from among aminoglycosides, beta-lactams, glycopeptides, macrolides, lincosamides, fluoroquinolones, amphenicoles, and tetracyclines or quaternary ammonium salts, or other antibacterial matters that exhibit a synergistic or additive effect with the complex of antimicrobial peptides. The new method allows for: reducing the antibiotic or antiseptic concentration needed for disrupting biofilms and preventing biofilm formation； decreasing an adverse aftereffect of bacterial infection chemotherapy； extending a list of antibiotics suitable for treating the biofilm infections, for disinfecting the implants, for the hygienic purposes, as well as changing from the systemic administration of antibiotic to the local administration of antibiotics directly to the nidus of infection.La présente invention concerne les domaines de la médecine, de l'hygiène, de la cosmétologie et de la médecine vétérinaire et peut être utilisée pour prévenir la formation de biofilm bactérien et rompre des biofilms formés par des bactéries pathogènes et opportunistes de différents types au niveau d
