PROCEDE DE PREPARATION DE METHYL-{4,6-DIAMINO-2-[1-(2-FLUOROBENZYL)-1H-PYRAZOLO[3,4-B]PYRIDINO-3-YL]PYRIMIDINO-5-YL}METHYLCARBAMATE ET D'EPURATION DE CE COMPOSE POUR SON UTILISATION EN TANT QU'AGENT PHARMACEUTIQUE
MAIS, FRANZ-JOSEF,REHSE, JOACHIM,JOENTGEN, WINFRIED,SIEGEL, KONRAD
申请号：
CA2936852
公开号：
CA2936852C
申请日:
2010.11.22
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
The present invention relates to a process for preparing methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3- yl]pyrimidin-5-yl}methylcarbamate of the formula (I) (see formula I) and to a process for purifying the crude product of the compound of the formula (I) for use as pharmaceutically active compound, where, for purification, methyl {4,6-diamino-2-[1-(2-fluorobenzyl)- 1H-pyrazolo [3,4-b]pyridin-3 -yl] pyrimidin-5-yl} methylcarbamate sulphinyldimethane (1:1), i.e. a compound of the formula (II), is isolated as intermediate or is generated as intermediate in this purification process, if appropriate present in a mixture.
