PROBLEM TO BE SOLVED: To solve such a problem in which, if a high function of a graft cell such as a hepatoblast is aimed for improving effect or engraftment of hepatocyte transplantation, administration to a portal causes increase of risk of embolus, and there is risk in a clinical field, originally a liver is maintained by a high pressure system through a hepatic artery and a low pressure system through a portal, especially the latter is important for increase of hepatic cells, if newly created hepatic tissue created in a test tube is implanted without vascular anastomosis of the above-mentioned two systems, an artery system being a blood capillary flows and the implanted tissue does not grow.SOLUTION: The invention relates to a formulation containing hepatic cells, and is implanted to a liver isolation surface of a living body, preferably a liver isolation surface of a human body for reproducing a hepatic tissue. The formulation causes no risk such as embolus relative to a conventional method, and efficiency of engraftment is improved.SELECTED DRAWING: NoneCOPYRIGHT: (C)2017,JPO&INPIT【課題】肝細胞移植の生着や効果を上げるために、肝芽細胞のように移植細胞の高機能化を図れば、門脈への投与は塞栓のリスクが高まり臨床では危険である。本来、肝臓は肝動脈を介した高圧系と門脈を介した低圧系で維持されており、 特に後者が肝細胞の増殖に必要である。試験管内で新に作製した肝組織を前述の2系統の血管吻合なしに移植すると、毛細血管である動脈系が流入して、移植組織が育たない等の課題があった。【解決手段】本発明は、肝細胞を含み、生体の、好ましくはヒトの肝臓切離面に移植して、肝組織を再生するための製剤を提供する。この製剤により、従来方法に比べ塞栓等の危険がなく生着効率が改善される。【選択図】なし
