new derivatives of 3,4 - dihydroizochinolino - 3 - carboxylic anticancer properties, their synthesis, pharmaceutical compositions containing these derivatives, and their use
The object of the invention is 3,4-dihydroisoquinoline derivative of structure represented by formula I, wherein R1is selected from the group consisting of H, COOEt, COOH, COOBn； R2 is selected from the group consisting of H, COOEt, COOH, COOBn； R3is selected from the group consisting of OH, OBn； R4is selected from the group consisting of OH, H, OBn； Rsis selected from the group consisting of OH, OBn； and isomers, salts, hydrates and solvates thereof, as well as the method of preparation thereof； pharmaceutical composition comprising the above mentioned derivative and use thereof.
