Hiroyuki Koshio,Karl Bruce Thor,Keiko Kawabata,Norio Asai,Taisuke Takahashi,Takafumi Shimizu,Yasuhito Nagai
申请号：
BR112012022915
公开号：
BR112012022915A2
申请日:
2011.03.11
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
benzazepine compound. A compound is provided which is useful as an agent for treating or preventing 5-ht-2c-receptor-related diseases, specifically incontinence, such as stress urinary incontinence, urge urinary incontinence, mixed urinary incontinence and the like, sexual dysfunction. , such as erectile dysfunction syndrome and the like, obesity, and the like. means of solution. The present inventors have studied compounds exhibiting a 5-ht-2c-receptor agonist activity which is promising as an active ingredient in a pharmaceutical composition for treating or preventing incontinence, such as stress urinary incontinence, urge urinary incontinence, incontinence mixed urinary tract and the like, sexual dysfunction such as erectile sexual dysfunction syndrome and the like, obesity and the like and found that the benzazepine compounds of the present invention exhibit excellent 5-ht-2c receptor antagonist activity whereby, supplementing the present invention. that is, the benzazepine compounds of the present invention exhibit 5-ht-2c-receptor agonist activity and may be employed as an agent for treating or preventing 5-ht-2c-receptor-related diseases, specifically incontinence, such as, stress urinary incontinence, urge urinary incontinence, mixed urinary incontinence and the like, sexual dysfunction such as erectile dysfunction syndrome and the like, obesity, and the like.composto de benzazepina. é fornecido um composto que é útil como um agente para tratamento ou prevenção das doenças relacionadas ao receptor 5-ht~ 2c~, especificamente incontinência, tal como, incontinência urinária de esforço, incontinência urinária de urgência, incontinência urinária mista e semelhantes, disfunção sexual, tal como, síndrome de disfunção erétil e semelhantes, obesidade, e semelhantes. meios de solução. os presentes inventores estudaram os compostos apresentando uma atividade agonista do receptor 5-ht~ 2c~, que é promissor como ingrediente ativo de uma composição farmacêutica para trata
