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1-phenylpyrrole derivatives
专利权人:
Raju Mohan;Kazumasa Aoki;Richard Martin;Masatoshi Honzumi;Tie-Lin Wang;Tsuyoshi Homma;John Nuss;Hiroyuki Tsuruoka;Matthew Williams;Keiji Saito;Yusuke Asoh
发明人:
John Nuss,Matthew Williams,Raju Mohan,Richard Martin,Tie-Lin Wang,Hiroyuki Tsuruoka,Kazumasa Aoki,Masatoshi Honzumi,Yusuke Asoh,Keiji Saito,Tsuyoshi Homma
申请号:
US13122239
公开号:
US08642640B2
申请日:
2009.10.07
申请国别(地区):
US
年份:
2014
代理人:
摘要:
The present invention comprises a compound for the prevention and/or treatment of cardiovascular diseases, nephropathy, fibrosis, primary aldosteronism or edema. The compound is of the following general formula (I): wherein R1 represents a C1-C3 alkyl group; R2 represents a hydroxy-C1-C4 alkyl group and the like; R3 represents a halogeno group, a halogeno-C1-C3 alkyl group and the like; R4 represents a hydrogen atom, a halogeno group and the like, —R5 represents a sulfamoyl group or a C1-C3 alkylsulfonyl group; R6 represents a hydrogen atom, a halogeno group and the like] or an N-oxide, atropisomer of the foregoing, or pharmaceutically acceptable salt of the foregoing.
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