ANTHONY QUINN,JOSEPH VICTOR RUTKOWSKI,MARKLEY C LEAVITT,XIA ZHINAN
申请号：
BR112014008873
公开号：
BR112014008873A2
申请日:
2012.10.11
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
The present invention provides compositions comprising an isolated mixture of recombinant human NaGlu proteins in which a substantial amount of the NaGlu proteins in the mixture has increased levels of phosphorylated mannose that confer the proteins to be efficiently internalized into human cells. The present invention also provides methods of producing such mixture of NaGlu proteins, vectors used in transgenesis and expression, host cells harboring such vectors, and methods of isolating and purifying the mixture of NaGlu proteins. The invention further provides methods of treating NaGlu associated diseases.
