Peter Bergsagel;Alexander Keith Stewart;Esteban Braggio;Rafael Fonseca
发明人:
Alexander Keith Stewart,Peter Bergsagel,Rafael Fonseca,Esteban Braggio
申请号:
US14003622
公开号:
US20140066480A1
申请日:
2012.03.08
申请国别(地区):
US
年份:
2014
代理人:
摘要:
This document provides methods and materials related to assessing responsiveness to lenalidomide, thalidomide, and/or other IMiDs (structural and functional analogues of thalidomide that represent a promising new class of immunomodulators). For example, methods and materials for using CRBN levels to determine whether or not cancer cells (e.g., multiple myeloma cells) are susceptible to lenalidomide, thalidomide, and/or other IMiDs are provided.