Microcapsule suspension in a liquid, aqueous phase that allows the modified release of at least one active ingredient, excluding amoxicillin and intended to be administered orally, characterized: in that it comprises a plurality of microcapsules each consisting of a heart It comprising at least one active principle (excluding amoxicillin) and a coating film
- modified governing release - applied to the heart,
the (or) principle (s) active (s)
- and having a composition corresponding to one of three families a, B, C following:
- Family a:
- 1A - at least one insoluble film-forming polymer (P1) in the gastrointestinal tract fluids, present in a proportion of 50 to 90%, preferably 50 to 80% by dry weight with respect to the total mass of the coating composition and constituted by at least one water-insoluble derivative of ce cellulose
- 2A - at least one nitrogenous polymer (P2) present at 2 to 25%, preferably 5 to 15% by dry weight, relative to the total mass of the coating composition and consists of at least one polyacrylamide and / or poly-N-vinylamide and / or poly-N-vinyllactam
- 3A - at least one, dry, with respect to the total mass of the coating composition and constituted by the plasticizer present at 2 to 20%, preferably 4 to 15% by weight least one of the following compounds: glycerol esters, phthalates, citrates, sebacates, cetyl alcohol esters, castor oil
- 4A - at least one surfactant and / or lubricant present agent at 2 to 20%, preferably 4 to 15% by dry weight, relative to the total mass of the composition coating and chosen from anionic and / or from nonionic and / or between lubricating agents said agent being able to comprise one or a mixture of these products
- Family B:
- 1B - at least one hydrophilic polymer carrying groups ionized at neutral pH, preferably chosen from cellulose derivatives
