Nicholas C. Prairie;Maria L. Ufret;Jundong Zhang;Deborah M. Rothman;Jeanne Mary Comstock;Zheng Xin Dong
发明人:
Zheng Xin Dong,Nicholas C. Prairie,Maria L. Ufret,Jundong Zhang,Deborah M. Rothman,Jeanne Mary Comstock
申请号：
US13386220
公开号：
US20120190616A1
申请日:
2010.07.22
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to novel analogues of insulin-like growth factor-1 (IGF-1), pharmaceutical compositions containing said analogues, and the use of said analogues for treatment of IGF-1-receptor mediated conditions, such as short stature, diabetes therapy, neurodegenerative disease treatment, and cartilage repair. More particularly, the present invention relates to novel analogues of IGF-1 having an amino acid substitution at position 59, e.g., (Asn59)hIGF-1(1-70)-OH (SEQ ID NO:1), and other substitution(s) as defined herein.
