The invention provides a combination comprising (a) S-[2-([[1-(2-ethylbutyl)cyclohexyl]carbonyl]amino)phenyl]2-methylpropanethioate or prodrug of the active form thereof, and (b) at least one HMG CoA reductase inhibitor. Also provided are pharmaceutical composition, package, and a kit comprising the aforementioned active ingredients, as well as a method for treatment and prophylaxis of a cardiovascular disorder involving the use of the aforementioned active ingredients.本發明提供一種組合,其包含(a) S-[2-([[1-(2-乙基丁基)環己基]羰基]胺基)苯基]2-甲基丙烷硫酯或其活性形式的前藥,及(b)至少一種HMG CoA還原酶抑制劑。同時本發明提供一種醫藥組成物、包裝及一種套組,其包含前述活性成分,以及一種涉及前述活性成分之使用的治療或預防心血管病的方法。