The invention relates to novel piperazine derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including pharmaceutical compositions containing one or more of those compounds and their use as medicaments for the treatment or prevention of protozoal infections, such as especially malaria.本發明係關於一種新穎哌衍生物及其作為製備醫藥組合物中之活性成分之用途。本發明亦關於相關態樣,其包括含有一或多種該等化合物之醫藥組合物及其作為治療或預防原蟲感染(如尤其係瘧疾)之藥物之用途。