A laser interlock system and allows laser radiation to be generated when an inspector and a subject correctly wear safety glasses and during use of a photo-acoustic imaging apparatus, thereby protecting the eyes of the inspector and the subject and preventing unnecessary power consumption. The laser interlock system includes a sensing unit to sense whether or not contact between a user and safety glasses occurs, a light source unit to generate a laser, and a control unit that determines, based on an output value from the sensing unit, whether or not the user is wearing the safety glasses normally, and generates an interlock signal to turn on or off the light source unit for selective laser generation according to the determination.