您的位置: 首页 > 农业专利 > 详情页

OLIGONUCLEOTIDE A ACTIVITE TGF-BETA MODIFIE POUR UTILISATION DANS UNE METHODE DE PREVENTION ET/OU DE TRAITEMENT D'UNE MALADIE OPHTALMIQUE
专利权人:
ISARNA THERAPEUTICS GMBH
发明人:
JASCHINSKI, FRANK,JANICOT, MICHEL,UHLMANN, EUGEN,LEO, EUGEN
申请号:
CA2908101
公开号:
CA2908101A1
申请日:
2014.03.27
申请国别(地区):
CA
年份:
2014
代理人:
摘要:
The invention refers to an oligonucleotide consisting of 10 to 20 nucleotides of selected regions of the TGF-beta1, TGF-beta2 or TGF-beta3 nucleic acid sequence, which comprises modified nucleotides such as LNA, ENA, polyalkylene oxide-, 2'-fluoro, 2'-O- methoxy and/or 2'-O-methyl modified nucleotides. The invention further relates to pharmaceutical compositions comprising such oligonucleotide, wherein the composition or the oligonucleotide is used in a method for the prevention and/or treatment of glaucoma, posterior capsular opacification, dry eye, Marfan or Loeys- Dietz syndrome, riboblastoma, choroidcarcinoma, macular degeneration, such as age- related macular degeneration, diabetic macular endma, or cataract.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充