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СЛОЖНЫЕ ЭФИРЫ ДАБИГАТРАНА АМИДОКСИМА КАК ПРОЛЕКАРСТВА И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ФАРМАЦЕВТИЧЕСКИХ СРЕДСТВ
专利权人:
ДРИТТЕ ПАТЕНТПОРТФОЛИО БЕТАЙЛИГУНГСГЕЗЕЛЬШАФТ МБХ УНД КО. КГ (DE)
发明人:
КЛЕМЕНТ Бернд (DE),КОТТХАУЗ Юрке (DE),КОТТХАУЗ Йоша (DE),ШАДЕ Деннис (US)
申请号:
RU2014106866/04
公开号:
RU2014106866A
申请日:
2012.07.05
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. A compound of the formula in a kotoroyRpredstavlyaet -H, a branched or unbranched, saturated or unsaturated, substituted or unsubstituted hydrocarbon chain length of from 1 to 12 carbon atoms, and n is 1-10, and a pharmaceutically acceptable proizvodnye.2. A compound according to claim 1, wherein n is 2.3. A compound according to claim 1, wherein a Rpredstavlyaet etil.4. The compound of claim 1 which is a salt, solvate, solvate and soli.5. A compound according to any one of claims 1-4 for the treatment and / or prophylaxis zabolevaniy.6. The compound of any of claims 1-4 but for use in the treatment and / or prevention of thrombotic bolezney.7. A compound according to any one of claims 1-4 for use in the treatment and / or prevention of thrombotic events such as thromboembolism (VTE) .8. The compound of any of claims 1-4 but for use in the treatment and / or prevention of stroke, myocardial infarction and / or cardiac fibrillation and atrial aritmii.9. A compound according to any one of claims 1-4 for use in the treatment and / or prevention of cancer of any patogeneza.10. A medicament comprising at least one compound according to any one of claims 1-4, having an effect on prolonging thrombin time, a thrombin inhibiting effect on and / or inhibitory effect on related serinproteazy.11. A medicament comprising at least one compound according to any one of claims 1-4, if appropriate in combination with one or more inert non-toxic pharmaceutically acceptable ekstsipientami.12 suitable. A medicament comprising at least one compound according to any one of claims 1-4 in combination with one or more other active agents1. Соединение формулы,в которойR1 представляет собой -H, разветвленную или неразветвленную, насыщенную или ненасыщенную, замещенную или незамещенную углеводородную цепь длиной от 1 до 12 атомов углерода, иn равен 1-10,а также его фармацевтически приемлемые производные.2. Соединение по п.1, при этом n равен 2.3. Соединение по п.1, при этом R1 представляет с
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