Antibodies specific to trophoblast antigen 2 (TROP2) and uses thereof for therapeutic and diagnostic purposes. Also provided herein are chimeric antigen receptors (CARs) comprising an extracellular antigen-binding fragment that binds TROP2 and immune cells expressing such.滋養層抗原2 (trophoblast antigen 2,TROP2)特異性抗體及其在治療及診斷中之用途。本文還提供了嵌合抗原受體(chimeric antigen receptors,CARs),其包含與TROP2結合的一胞外抗原結合片段以及表現該片段的免疫細胞。