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ИММУНОМОДУЛИРУЮЩИЕ СПОСОБЫ И СИСТЕМЫ ДЛЯ ЛЕЧЕНИЯ И/ИЛИ ПРЕДОТВРАЩЕНИЯ ГИПЕРТЕНЗИЙ
专利权人:
СЕДАРС-СИНАИ МЕДИКАЛ СЕНТЕР (US)
发明人:
ЧИУ Куанг-Юх (US),ШАХ Предиман К. (US)
申请号:
RU2013126626/10
公开号:
RU2013126626A
申请日:
2011.11.11
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A method for the treatment and / or prevention of hypertension and / or associated with her condition in a subject, wherein the method includes sebyavvedenie individual an effective amount of one or more of the immunogenic fragments of ApoB-100, or an immunogenically active part, wherein the immunogenic fragment comprises one of SEQ ID NO: 1-302, wherein one or more immunogenic fragments or immunogenically active parts associated with decreasing ateroskleroza.2. The method of claim 1, wherein one or more immunogenic fragments contain one or more peptides wherein each contains one of SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 11, SEQ ID NO: 25, SEQ ID NO : 45, SEQ ID NO: 74, SEQ ID NO: 99, SEQ ID NO: 100, SEQ ID NO: 102, SEQ ID NO: 103, SEQ ID NO: 105, SEQ ID NO: 129, SEQ ID NO: 143 , SEQ ID NO: 148, SEQ ID NO: 210 or SEQ ID NO: 301.3. The method of claim 1, wherein one or more immunogenic fragments contain one or more peptides wherein each contains one of SEQ ID NO: 2, SEQ ID NO: 11, SEQ ID NO: 45, SEQ ID NO: 74, SEQ ID NO : 102, SEQ ID NO: 148 or SEQ ID NO: 210.4. The method of claim 1, wherein one or more immunogenic fragments comprise a peptide having SEQ ID NO: 143 and peptide having SEQ ID NO: 210.5. The method of claim 1, wherein one or more immunogenic fragments comprise a peptide having SEQ ID NO: 11, the peptide having SEQ ID NO: 25 and peptide having SEQ ID NO: 74.6. The method of claim 1, wherein one or more immunogenic fragments comprise a peptide having SEQ ID NO: 2.7. The method of claim 1, wherein one or more immunogenic fragments comprise a peptide having SEQ ID NO: 45.8. The method of claim 1, wherein one or more immunogenic fragments comprise a peptide having SEQ ID NO: 210.9. A method according to any one of claims. 1-8, where the individual is a human and the concentration is between about 100 micrograms and about less than 1 mg.10. A method according to any one of claims. 1-8 g1. Способ лечения и/или предотвращения гипертензии и/или ассоциированн
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