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A peptidomimetic derivative of erythropoietin and its pharmaceutical salt, the preparation and uses thereof
专利权人:
JIANGSU HANSOH PHARMACEUTICAL CO.; LTD.
发明人:
LÜ, AIFENG,SUN, CHANGAN,JIANG, TAO,WU, WENTAO,WANG, YALI
申请号:
ES08865748
公开号:
ES2541139T3
申请日:
2008.11.24
申请国别(地区):
ES
年份:
2015
代理人:
摘要:
A peptidomimetic derivative of erythropoietin (EPO) of general formula (I) and its pharmaceutically acceptable salts, R1-R2- (CH2) n1-R3- (CH2) n2-R4-R5 (I) in which R1, R5 are selected among cyclic peptides having the following sequences: ** Formula ** in which n1, n2 are integers independently selected from 0 to 10; wherein R2, R4 are selected from -CO or -CH2; wherein R3 is selected from NCO (CH2) n4NHR6, CHOCONH (CH2) n5NHR6, or CHSCON (CH2) n5NHR6; in which n4 is an integer selected from 2 to 10, in which n5 is an integer selected from 2 to 10, and in which R6 is selected from H or methoxy-polyethylene glycol derivatives.Un derivado peptidomimético de eritropoyetina (EPO) de fórmula general (I) y sus sales farmacéuticamente aceptables, R1-R2-(CH2)n1-R3-(CH2)n2-R4-R5 (I) en la que R1, R5 se seleccionan entre péptidos cíclicos que tiene las siguientes secuencias:**Fórmula** en las que n1, n2 son números enteros seleccionados independientemente entre de 0 a 10; en las que R2, R4 se seleccionan entre -CO o -CH2; en las que R3 se selecciona entre NCO(CH2)n4NHR6, CHOCONH(CH2)n5NHR6, o CHSCON(CH2)n5NHR6; en las que n4 es un número entero seleccionado entre de 2 a 10, en las que n5 es un número entero seleccionado entre de 2 a 10, y en las que R6 se selecciona entre H o derivados de metoxi-polietilenglicol.
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