COMEAU STEPHEN R,NIXON ANDREW,KASTRAPELI NIKSA,KENNISTON JON A,CONLEY GREGORY P,MASON SHAUNA,LINDBERG ALLISON P,KOPACZ KRISTOPHER,ADELMAN BURT
申请号：
IN201717027461
公开号：
IN201717027461A
申请日:
2017.08.02
申请国别(地区):
IN
年份:
2017
代理人:
摘要：
Described herein are bispecific antibodies that bind to plasma kallikrein (pKal) and Factor XII and methods of producing and using such bi specific antibodies for treating diseases or disorders associated with the contact system e.g. hereditary angioedema or thrombosis. One aspect of the present disclosure is a bispecific antibody comprising: a first polypeptide that comprises a light chain of a first antibody the light chain comprising a light chain variable region (VL) and a light chain constant region (CL) (e.g. a kappa light chain or a lambda light chain)； and a second polypeptide that comprises a heavy chain of the first antibody the heavy chain comprising a heavy chain variable region (VH) and a heavy chain constant region (CH).
