DRITTE PATENTPORTFOLIO BETEILIGUNGSGESELLSCHAFT MBH & CO. KG
发明人:
CLEMENT, PROF. DR. BERND,KOTTHAUS, DR. JOSCHA,KOTTHAUS, JUERKE,SCHADE, DENNIS DR.
申请号：
EP11175230.9
公开号：
EP2550966A1
申请日:
2011.07.25
申请国别(地区):
EP
年份:
2013
代理人:
摘要：
Die vorliegende Erfindung betrifft Prodrug-Derivate des Dabigatrans, ihre Verwendung zur Behandlung und/oder Prophylaxe von Krankheiten, insbesondere von thrombotischen Werkrankungen, von Schlaganfall, Herzinfarkt und/oder Vorhofflimmern und Arrhythmien, sowie von onkologischen Erkrankungen jeglicher Pathogenese.Substituted dabigatran compounds (I) are new. Substituted dabigatran compounds of formula (I) and their derivatives, salts, solvates, or the solvates of salts are new. R1 : H or optionally branched, optionally saturated and optionally substituted 1-12C-hydrocarbon chain and n : 1-10. Independent claims are included for: (1) a drug comprising (I) in combination with one or more further active agents and (2) the preparation of (I). [Image] ACTIVITY : Hemostatic Thrombolytic Cerebroprotective Vasotropic Cardiant Antiarrhythmic Cytostatic. MECHANISM OF ACTION : Serine protease inhibitor.
