The present invention is directed to A pharmaceutical composition in the form of an effervescent tablet comprising:(a) 1200 mg ofN-acetylcysteine and(b) at least 1200 mg of sodium hydrogen carbonate and(c) less than 1200 mg of anhydrous citric acid and(d) at least one lubricant and/or glidant agent and(e) at least one sweetener and/or flavouring agent andsaid pharmaceutical composition having no sulfur smell and taste as well as a pH in the range of 4.1 and 4.4 after tablet dissolution.A manufacturing process is also disclosed.The claimed pharmaceutical composition is used in the treatment of abnormal, viscid, or inspissated mucous secretions.