A method for increasing the temporal fidelity, increasing the temporal sampling density, and/or reducing the temporal noise of a series of image frames obtained with a medical imaging system is provided. The image frames are acquired with the medical imaging system. The medical imaging system may be, for example, an x-ray C-arm imaging system. A window function that is representative of a temporal fidelity window is selected and used to temporally deconvolve the image frames using a minimization technique. A temporal sampling density may also be selected and used in the temporal deconvolution. The resultant deconvolved image frames have a higher temporal fidelity to a time-varying image contrast depicted in the acquired image frames, and may also have an increased temporal sampling density and/or reduced temporal noise.
