MacDonald Lynn,Murphy Andrew J.,Voronina Vera,Gurer Cagan
申请号：
US201414185316
公开号：
US10154658(B2)
申请日:
2014.02.20
申请国别(地区):
美国
年份:
2018
代理人:
FisherBroyles, LLP `Wu Rita S.`Zippin Margarita
摘要：
The invention provides genetically modified non-human animals that express chimeric human/non-human MHC I and MHC II polypeptides and/or human or humanized β2 microglobulin polypeptide, as well as embryos, cells, and tissues comprising the same. Also provided are constructs for making said genetically modified animals and methods of making the same. Methods of using the genetically modified animals to study various aspects of human immune system are provided.
