Kenneth L. Arrington,Vadim Dudkin,Mark E. Layton,Joseph E. Pero,Alexander J. Reif
申请号：
US13701039
公开号：
US08765784B2
申请日:
2011.06.06
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention is directed to 5-substituted 1,3-dihydro-2H-imidazo[4,5-b]pyridine-2-one derivatives which are positive allosteric modulators of the mGluR2 receptor, useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 receptor is involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved, such as schizophrenia.
