Albert Einstein College of Medicine;Vitrisa Therapeutics, Inc.
发明人:
Carl Erickson,Christopher P. Rusconi,Kevin G. McLure,Matthew Levy,Arijit Bhowmick
申请号：
US16541482
公开号：
US20200216849A1
申请日:
2019.08.15
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The application discloses methods and compositions for the inhibition of the alternative complement pathway. The methods and compositions involve the use of aptamers for inhibiting complement Factor D. The application further provides anti-Factor D aptamers for the treatment of dry age-related macular degeneration, geographic atrophy, wet age-related macular degeneration or Stargardt disease. In some cases, stem-loop aptamers are provided for the inhibition of Factor D.
