A distance from a printing section to a heat sealing section of a medicine packaging apparatus is shortened without generating wrinkles on a package sheet. A unfolding guide 65 included in a packaging unit 4 for unfolding and opening a package sheet 61 has a main ridge 94 extending along with the fold of the package sheet 61, and a pair of unfolding guide surfaces 90a, 90b which are convex curved surfaces stretching from the main ridge 94 and which are symmetrical to each other with respect to the main ridge 94.
