Min Wang,Patrick M. Hossler,Sean W. McDermott,Christopher Racicot,Kofi Chemfe,John Fann
申请号：
US14270675
公开号：
US09416181B2
申请日:
2014.05.06
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Supplementation of the bioflavonoids such as epigallocatechin gallate, rutin, naringin, or genistein into mammalian cell culture media are shown to be effective in reduction of acidic species variants on recombinant antibodies. The demonstrated reduction in acidic species through the use of bioflavonoids, facilitates the manufacturing of a less heterogeneous product with potential improvements in antibody structure and function.
