A compound of the formula: ** Formula ** and pharmaceutically acceptable salts and stereoisomers thereof； where y is 0 or 1； n and p are each independently selected from 0, 1 or 2； R14 is C (O) or SO2； R1, R2, W, R13 and V are each independently selected from hydrogen or from the group consisting of alkyl, alkyl-aryl, heteroalkyl, heterocyclyl, heteroaryl, aryl-heteroaryl, alkyl-heteroaryl, cycloalkyl, alkyloxy, alkyl- aryloxy, aryloxy, heteroaryloxy, heterocyclyloxy, cycloalkyloxy, amino, alkylamino, arylamino, alkyl-arylamino, arylamino, heteroarylamino, cycloalkylamino, carboxyalkylamino, mono- and di-alkylcarboxamide, aralkyloxy and heterocyclylamino； each of which can be independently substituted one or more times with X1 and X2； wherein X1 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkyl-alkyl, heterocyclyl, heterocyclylalkyl, aryl, alkylaryl, aralkyl, aryloxy, arylthio, arylheteroaryl, heteroaryl, heterocyclylamino, alkylheteroaryl, or heteroaralkyl； wherein X1 can be independently substituted with one or more structural units X2 that can be the same or different and are independently selected； wherein X2 is hydroxy, oxo, alkyl, cycloalkyl, spirocycloalkyl, heterocycloalkyl, aryl, heteroaryl, alkoxy, aryloxy, thio, alkylthio, amino, mono- and di-alkylamino, arylamino, alkylsulfonyl, arylsulfonyl, alkylsulfonamido, arylsulfonamido, carboxylambal, , carboxamido, alkoxycarbonylamino, alkoxycarbonyl, alkoxycarbonyloxy, alkylureido, arylureido, halogen, cyano, or nitro； wherein each residue X2 selected to be alkyl, alkoxy, and aryl may be unsubstituted or optionally substituted independently with one or more structural units which may be the same or different and are independently selected from alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkyl -alkyl, heterocyclyl, heterocyclylalkyl, aryl, alkylaryl, aralkyl, arylheteroaryl, heteroaryl, heterocyclylamino, alkylheteroaryl and heteroaralkyl； W is also selected from the group consisting of C (O) -C (O) H, C (>； = N
