Carlos GARCIA GONZALEZ,Luis A DIAZ GOMEZ,Carmen ALVAREZ LORENZO,Angel J CONCHEIRO NINE
申请号：
US15746726
公开号：
US20180236086A1
申请日:
2016.07.12
申请国别(地区):
US
年份:
2018
代理人:
摘要：
A system for administering biologically active substances produced by foaming techniques using compressed gases or supercritical fluids relates to a porous system containing biologically active substances. The system includes a polymer matrix of poly(D,L-lactic-co-glycolic acid) or a polymer mixture containing poly(D,L-lactic-co-glycolic acid) of an intrinsic viscosity of less than 0.5 dL/g with other biodegradable synthetic or semisynthetic polyesters, a release-regulating component (starch and derivatives), and at least one biologically active substance. The matrix is biodegradable with a solid or semisolid consistency and a homogeneous appearance. A method for producing these systems using foaming with compressed fluids, and the use for the production of implants and scaffolds having this system are also disclosed. Optionally, a porogenic agent can be used for the formation of macropores by thermal decomposition.
