KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
发明人:
KANG, Jong Soon,강종순,PARK, Kee Hwan,박기환,LEE, Chang Woo,이창우,KIM, Hyoung-Chin,김형진,OH, Soo Jin,오수진,YUN, Ji Eun,윤지은
申请号：
KRKR2013/001376
公开号：
WO2013/187575A1
申请日:
2013.02.21
申请国别(地区):
WO
年份:
2013
代理人:
摘要：
The present invention relates to a pharmaceutical composition or health food comprising hypothemycin as an active ingredient for preventing and treating macrophage activation syndrome, hepatocirrhosis, or obesity. More particularly, since hypothemycin according to the present invention inhibits the production of TNF-α and the expression of TNF-α mRNA caused by activated macrophages, hypothemycin can be effectively used as an active ingredient for a pharmaceutical composition or health food for preventing and treating macrophage activation syndrome, hepatocirrhosis, or obesity, which are diseases induced by activated macrophages.La présente invention concerne une composition pharmaceutique ou un aliment naturel comprenant de lhypothémycine en tant que principe actif pour la prévention et le traitement du syndrome de lactivation des macrophages, de la cirrhose du foie ou de lobésité. Plus particulièrement, étant donné que lhypothémycine selon la présente invention inhibe la production de TNF-α et lexpression de TNF-α ARNm provoquée par des macrophages activés, lhypothémycine peut être utilisée efficacement en tant que principe actif pour une composition pharmaceutique ou un aliment naturel pour la prévention et le traitement du syndrome de lactivation des macrophages, de la cirrhose du foie ou de lobésité, qui sont des maladies induites par des macrophages activés.【요약서】 본 발명은 하이포테마이신을 유효성분으로 포함하는 대식세포 활성화 증후군, 간경화 또는 비만의 예방 및 치료용 약학적 조성물, 또는 건강식품에 관한 것으로, 보다 상세하게는 본 발명의 하이포테마이신은 활성화된 대식세포에 의한 TNF-α생성 및 TNF-α mRNA 발현을 억제하므로, 하이포테마이신을 활성화된 대식세포에 의하여 유도되는 질환인 대식세포 활성화 증후군, 간경화, 또는 비만의 예방 및 치료용 약학적 조성물 또는 건강식품의 유효성분으로 유용하게 사용될 수 있다.
