The present invention relates to a compound or combination for use in the treatment of skin wounds, skin aging, skin tumors and/or skin sensation conditions and/or for treatment to improve skin repair, wherein the compound or combination is: (a) a selective delta-opioid receptor (DOR) antagonist； or (b) a combination of a selective DOR antagonist and an opioid receptor agonist； or (c) a selective ligand for a sensory receptor； or (d) a combination of a selective DOR antagonist and a selective ligand for a sensory receptor； or (e) a combination of a selective DOR antagonist, an opioid receptor agonist and a selective ligand for a sensory receptor, and wherein the treatment comprises a step of administering an effective amount of the compound or combination to a subject in need of such treatment.
