JENMALM JENSEN, ANNIKA,LEHMANN, FREDRIK,NILSSON, BJÖRN M.,NORDLING, ERIK,PARROW, VENDELA
申请号：
HRP20140547
公开号：
HRP20140547T1
申请日:
2014.06.10
申请国别(地区):
HR
年份:
2014
代理人:
摘要：
The present invention relates to compounds of the general formula (I) wherein R 1 , R 2 and R 3 are as defined herein, which can act as inhibitors of protein kinases, specially the Fms-like tyrosine kinase 3 (FLT3). The invention also relates to the use of the compounds in therapy, pharmaceutical compositions comprising the compounds and the use of the compounds for the preparation of a medicament for the prophylaxis and treatment of hematological malignancies, such as AML, MLL, T-ALL, B-ALL and CMML, myeloproliferative disorders, other proliferative disorders like cancer, autoimmune disorders and skin disorders like psoriasis and atopic dermatitis.
