< Topic >The chemical compound which possesses the TAFIa inhibition activity which is superior is offered.Solutionsjihidoroimidazokinorin chemical compound or the medicine manufacture which is displayed with below-mentioned formula (i) the salt which is allowed study.However, in formula As for R, hydrogen atom or showing1-10 C alkyl group As for1 R, the hydrogen atom and C1-10 alkyl group, showing3-8 those which are displayed with structure of C shikuroarukiru or below-mentioned formula Ia and IbAs for3 R, showing1-6 C alkyl group As for4 R, C1-6 alkyl group, showing3-8 C shikuroarukiru , or benzyl basis2R hydrogen atom or below-mentioned expression Ic, shows those which are displayed with the structure of Id.< Choice figure >It is not【課題】優れたTAFIa阻害活性を有する化合物を提供する。【解決手段】下記式(I)で表されるジヒドロイミダゾキノリン化合物又はその製薬学的に許容される塩。ただし、式中;Rは、水素原子又はC1-10アルキル基を示し;R1は、水素原子、C1-10アルキル基、C3-8シクロアルキル基又は下記式Ia、Ibの構造で表されるものを示し;R3は、C1-6アルキル基を示し;R4は、C1-6アルキル基、C3-8シクロアルキル基、又はベンジル基を示し;R2は、水素原子又は下記式Ic、Idの構造で表されるものを示す。【選択図】なし
