The present application relates to a novel mutant protein derived from human lacrimal lipocalin, which binds to IL ￣ 4 receptor α.The sequence of the mutant protein contains a specific amino acid combination.In particular, there are mutated amino acid residues at any one or more of the linear polypeptide sequences of mature human lacrimal lipocalin at any one or more positions 27, 28, 30, 31, 33, 53, 57, 61, 64, 66, 80, 83, 104 ￣ 106 and 108.The amino acid residues were also found at any two or more positions of the linear polypeptide sequence of mature human lacrimal lipocalin at any two or more positions 26, 32, 34, 55, 56, 58 and 63.The invention also provides a corresponding nucleic acid molecule encoding the mutant protein and a method for producing the mutant protein and the nucleic acid molecule encoded therein.本申請涉及源自人淚脂質運載蛋白的新型突變蛋白，其與IL‑4受體α結合。所述突變蛋白的序列包含特定的氨基酸組合。特別地，在成熟人淚脂質運載蛋白線性多肽序列的序列位置27、28、30、31、33、53、57、61、64、66、80、83、104‑106和108中任一個或多個處存在突變的氨基酸殘基。在成熟人淚脂質運載蛋白線性多肽序列的序列位置26、32、34、55、56、58和63的任2個或更多個處也存在突變的氨基酸殘基。本發明還提供編碼這種突變蛋白的相應核酸分子以及用於產生這種突變蛋白和其編碼核酸分子的方法。
