Ali, Amjad,Lo, Michael Man-Chu,Metzger, Edward,Yan, Lin
申请号：
AU2011215881
公开号：
AU2011215881A1
申请日:
2011.02.10
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
A compound having the structure or a pharmaceutically acceptable salt thereof, wherein R is hydrogen, -OH, -O-C- alkyl, =O, or halogen；Ris hydrogen, C(O)OR, CHC(O)OR, (CH)OH, CRROH, C(O)O(CH) aryl, C(O)NRR, C(O)SONRR, CHOR, W-C(O)OR, W-OR, Y, or P(O)(OR)(ORlO)； R is hydrogen or -C alkyl； R is hydrogen, -OH or -C(O)OR； R is hydrogen or deuterium； R and R are independently-C alkyl, fluoro-substituted -C alkyl, deutero-substituted -C alkyl or -(CH)R, wherein any carbon atom of the fluoro-substituted -C alkyl is mono- or di-substituted with fluoro, and any carbon atom of the deutero-substituted -C alkyl is mono- or di-substituted with fluoro； R, in each instance in which it occurs, is independently hydrogen, -C alkyl, or -(CH)N(CH)； R and R, in each instance in which they occur, are independently -C alkyl； Ris -OH, -O-C alkyl, -0CD3, -OC(O)OC alkyl, -NH, -CH, -N, or W； W is an unsubslituted 5- or 6-raembered heteroaryl ring having 1, 2, or 3 nitrogen atoms, or a substituted 5- or 6-membered heteroaryl ring having 1, 2, or 3 nitrogen atoms that is mono- or di-substituted at any carbon atom with R or R； Y is a 5- or 6-membered heterocyclic ring having 1, 2, 3 or 4 heteroatoms which are N, O or S or stereoisomers thereof, or pharmaceutically acceptable salts thereof, or pharmaceutically acceptable salts of stereoisomers thereof, and methods of using the compounds for treating hypertension.
