The invention relates to a compound of formula I, its stereoisomer, enantiomer, medicinal salt or amino acid conjugates, in formula (I), each variable is as defined herein； the invention also relates to their pharmaceutical compositions, the compounds and pharmaceutical compositions of the invention can be used as a regulator of the activity of the farnesol X receptor (FXR).本發明涉及式I化合物、其立體異構體、對映體、可藥用的鹽或氨基酸軛合物，在式(I)中，各變量如本文所定義；本發明還涉及它們的藥用組合物，本發明的化合物和藥用組合物可以用作法尼醇X受體(FXR)活性的調節劑。
