The present disclosure provides a drug for preventing and treating alopecia and belongs to the technical field of pharmaceutical products. The drug for preventing and treating alopecia comprises the following active ingredients: a composition including more than one of flavonoid compound with effects of decreasing capillary permeability, calcium and vitamin C. The composition in the present disclosure can be adopted to achieve aims of effectively preventing and treating alopecia and promoting hair growth, and is safe in property, wide in universality, obvious in curative effects and suitable for treatment of androgenetic alopecia.