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DIAZACARBAZOLES ET PROCÉDÉS D'UTILISATION
专利权人:
GENENTECH; INC.
发明人:
申请号:
EP09762885.3
公开号:
EP2324024B1
申请日:
2009.06.10
申请国别(地区):
EP
年份:
2012
代理人:
摘要:
The invention relates to 1,5-diazacarbazole compounds of Formula (I), (I-a), (I-b), (I-c), (I-d), (I-e), (I-f), (I-g) and (I-h) which are useful as kinase inhibitors, more specifically useful as checkpoint kinase 1 (chk1) inhibitors, thus useful as cancer therapeutics. The invention also relates to compositions, more specifically pharmaceutical compositions comprising these compounds and methods of using the same to treat various forms of cancer and hyperproliferative disorders, as well as methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.
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中国工程科技知识中心
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