ОТАНИ Мицуаки (JP),МАЦУО Е (JP),ЛИ Инфу (US),УОКЕР Джоэл Р. (US),ДЖЕНКИНС Дэвид М. (US),АХМЕД Ферьян (US),ОСАВА Рюдзи (JP),ХИСАДА Содзи (JP)
申请号：
RU2011107227/13
公开号：
RU2011107227A
申请日:
2009.07.30
申请国别(地区):
RU
年份:
2012
代理人:
摘要：
1. The compound represented by formula (I) and a pharmaceutically acceptable salt, hydrate, solvate or isomer thereof:! ! where the ring A is represented by the formula:! ! where X is halogen or hydroxyl； ! Y represents hydrogen, phenyl, thiophen-2-yl, furan-2-yl, cyclopropyl or cyclopentyl； ! Z is a 5-10 membered heterocycle substituted carbonylamino； and! -L1- (CH2) a-L2-M is in the * position； ! where L1 is —CONH—, —NHCO— or a single bond； ! L2 is selected from the group consisting of —NH—, —O—, —CH (COOR1) -, —CH (CH2OH) -, —CH = CH— and a single bond, where R1 is hydrogen or C1-C6 alkyl； and! M is selected from the group consisting of hydroxyl, carboxyl, amide, C1-C6 alkyl, C1-C6 alkylcarbonyl, C6-C14 aryl, C6-C14 aryl C1-C6 alkyl, C6-C14 arylcarbonyl, C6-C14 arylsulfonyl, 5-14 membered saturated, unsaturated or aromatic heterocyclic group , C1-C6 alkyl substituted with a 5-14 membered unsaturated or aromatic heterocyclic group, sulfonyl substituted with a 5-14 membered unsaturated or aromatic heterocyclic group, and -NR2R3, where R2 and R3 independently represent C1-C6 alkyl； ! where C1-C6 alkyl, C1-C6 alkylcarbonyl, C6-C14 aryl, C6-C14 aryl C1-C6 alkyl, C6-C14 arylcarbonyl, C6-C14 arylsulfonyl, 5-14 membered unsaturated or aromatic heterocyclic group, C1-C6 alkyl substituted with a 5-14 membered an aromatic heterocyclic group, and a sulfonyl substituted with a 5-14 membered unsaturated or aromatic heterocyclic group is optionally substituted with 1-3 substituents, each independently selected from group A； ! where group A is selected from the group consisting of hydroxyl, oxo, nitro, amino, amide, halogen, sulfamoyl, trifluoromethyl, p-toluenesulfonylamino, C1-C6 alkyl1. Соединение, представленное формулой (I), и его фармацевтически приемлемая соль, гидрат, сольват или изомер: ! ! где кольцо A представлено формулой: ! ! где X представляет собой галоген или гидроксил； ! Y представляет собой водород, фенил, тиофен-2-ил, фуран-2-ил, циклопропил или цик
