BRUENING ERIC,FRUEH KLAUS,PICKER LOUIS,KORBER BETTE T M,THEILER JAMES,MARSHALL EMILY
申请号：
IN201737014998
公开号：
IN201737014998A
申请日:
2017.04.27
申请国别(地区):
IN
年份:
2017
代理人:
摘要：
Provided herein are HIV 1 vaccines comprising a carrier and a population episensus antigen determined using the EpiGraph approach. Also provided are HIV 1 vaccines comprising a carrier a population episensus antigen and a tailored antigen. Also provided are methods of designing and producing an HIV 1 vaccine for a subject comprising designing vaccine antigens to optimally cover the diversity within a geographic area using an antigen amino acid sequence generated using the EpiGraph approach and producing said designed vaccine antigen. Also provided are methods of inducing an effector memory T cell response comprising designing the one or more EpiGraph amino acid sequences producing a vaccine comprising the one or more EpiGraph amino acid sequences and a vector and administering the vaccine to a subject. Further provided are methods of treating HIV 1 in a subject comprising administering an effective amount of the described HIV 1 vaccines to the subject in need thereof.
