588545 An optical method for determining morphological parameters and physiological properties of tissue, the method comprising the steps of: generating, using an optical transfer diagnosis device, 30 reflectance images comprising reflectance measurements from a tissue area for 10 different wavelengths from multiple angles of illumination and detection and using the reflectance measurements to determine morphological parameters and physiological parameters. Determining the morphological parameters comprises using one of the 30 reflectance images for: determining a lesion border from the reflected intensity of the image of the lesion from a visible channel, measuring a size of the lesion, measuring a histogram-width that gives a measure of inhomogeneity of the reflected intensity of the lesion, capturing a relative moment of inertia of the lesion, determining a center distance representing a physical distance between a geometrical center of the lesion and a center of mass of absorptance, determining a fractal dimension of the lesion which describes the complexity of its border, determining an asphericity of the lesion, and determining a relative border length of the lesion. Determining the morphological and physiological parameters comprises, by using a bio-optical model, radiative transfer modeling, and a non-linear inversion procedure: systematically varying input values of the morphological parameters and physiological properties of the tissue while simultaneously varying inherent optical properties, the inherent optical properties being linked to the morphological parameters and the physiological properties of the tissue, computing reflectances by the radiative transfer model until an agreement between the reflectance measurements and reflectances computed by the radiative transfer model reaches a predetermined level of accuracy, and obtaining the morphological parameters and the physiological properties returned by the non-linear inversion procedure.
