KALOFONOS, Isabel,CARON, Judy,MARTIN-DOYLE, William
申请号：
RSP20150823
公开号：
RS54447B1
申请日:
2012.01.20
申请国别(地区):
RS
年份:
2016
代理人:
摘要：
Modified release pharmaceutical compositions of epalrestat are provided. Methods of manufacturing the tablets and treating various diseases and conditions, including diabetes and diabetic complications, by administering the modified release compositions to patients in need thereof. A modified release formulation of epalrestat or a pharmaceutically acceptable derivative thereof, which maintains an adequate epalrestat plasma concentration-time profile to effectively treat a patient in need thereof, using once-a-day administration. The modified release composition, in one embodiment, is a sustained release, controlled release, bi-modal release or delayed release composition. The modified release epalrestat pharmaceutical composition comprises a pharmaceutically acceptable epalrestat derivative, such as choline hydrogen diepalrestat or betaine hydrogen diepalrestat.Modifikovano oslobađajuća farmaceutska kompozicija koja obuhvata:epalrestat ili njegov farmaceutski prihvatljiv derivat；polimer koj bubri u vodi i nezavisan je od pH；anjonski polimer koji nije baziran na celulozi a koji bubri u vodi；i agens za podešavanje brzine oslobađanja baziran na saharidu.Prijava sadrži još 14 patentnih zahteva.
