The invention relates to a self-supporting sitting support and a wheelchair equipped therewith, wherein the sitting support comprises at least one frame, which frame is rigid to such an extent that it can maintain other parts fastened to the frame, for instance a substructure of a wheelchair, upright, and can absorb forces acting, during use, on the sitting support. The frame is for instance manufactured from one or more metal, double bent tube-shaped segments and is at least partly covered with a flexible, preferably somewhat elastic material, the arrangement being such that a profiled sitting support is obtained. The sitting support can further be provided with a transverse axis, which connects a bottom supporting part and a back supporting part with each other, such that between said parts a desired sitting angle can be set.