A deployment device, system, and method for deploying a prosthesis. The deployment device includes a housing, a rod disposed within the housing and adapted to rotate relative to the housing, and one or more support members (e.g., bushings, bearings, etc.) rotatably supporting the rod within the housing. An elongate slit is disposed in and entirely through the housing and is positioned in a way that enables the prosthesis to pass therethrough from a loaded, rolled configuration on the rod. The deployment device is generally flexible, e.g., has a bending stiffness of at most about 0.87 N/mm (e.g., about 0.05 N/mm to about 0.87 N/mm). Furthermore, the deployment device enables a user to deploy (e.g., unroll) a prosthesis therefrom at a rate determined manually by the user and in a piece-by-piece fashion.