The present invention relates to new receptor, homology cyclic peptide-mutant, it comprises only two cysteine residues that can form intramolecular bond, the nucleic acid molecule that relates to the linear peptides that can form these cyclic peptide-mutant and relate to these cyclic peptide-mutant of coding and linear peptides.And, the carrier that comprises said nucleic acid molecule and the method for recombinant host cell and the disclosed cyclic peptide-mutant of generation are provided.The composition that comprises peptide of the present invention, nucleic acid molecule, carrier or host cell also is provided.The present invention also relates to utilize means, method and the purposes of the treatment of peptide of the present invention and diagnosis and relate to and be used for detection type like anti--β 1Means, method and the purposes of the anti--receptor, antibody of-adrenoceptor antibody.
