Process for the preparation of GalNAc oligonucleotide conjugates

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专利权人:

F. Hoffmann-La Roche AG

发明人:

BREITLER, Simon

申请号：

AU2019213004

公开号：

AU2019213004A1

申请日:

2019.01.28

申请国别(地区):

AU

年份:

2020

代理人:

摘要：

The invention comprises a process for the preparation of GalNAc oligonucleotide conjugates which comprises the coupling of a GalNAc cluster compound of the formula or corresponding salts, enantiomers and/ or a stereoisomer thereof, with an oligonucleotide in the presence of an O-dicarboximidouronium salt as coupling agent.

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