This present invention relates to pharmacologically potent and stable human fibroblast growth factor 21 (FGF21) proteins, pharmaceutical compositions comprising FGF21 proteins, and methods for treating type 2 diabetes, obesity, dyslipidemia, and/or metabolic syndrome using such proteins.本發明係關於藥理學有效且穩定之人類纖維母細胞生長因子21(fibroblast growth factor 21;FGF21)蛋白質、包含FGF21蛋白質之醫藥組合物,及使用該等蛋白質治療II型糖尿病、肥胖症、異常血脂症及/或代謝症候群之方法。