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METHOD FOR PRODUCING 3-ARYLPROPIONAMIDE COMPOUND AND 3-ARYLPROPIONIC ACID ESTER COMPOUND
专利权人:
SUMITOMO CHEMICAL COMPANY, LIMITED
发明人:
TANIMURA, Shun,TANIMOTO, Masaya,HAGIYA, Koji
申请号:
WO2018JP20798
公开号:
WO2018221604(A1)
申请日:
2018.05.30
申请国别(地区):
世界知识产权组织国际局
年份:
2018
代理人:
摘要:
The present invention provides a method for industrially producing: a pyrimidine compound having pest control efficacy; 2-[4-(trifluoromethyl)phenyl]ethylamine, which is a production intermediate of the pyrimidine compound; a phenylethylamine compound useful as a medical and agricultural chemical intermediate; and a 3-arylpropionamide compound and a 3-arylpropionic acid ester compound which are useful as production intermediates of the phenylethylamine compound. The 3-arylpropionamide compound or the 3-arylpropionic acid ester compound can be effectively and industrially produced in a single step by reacting a compound represented by formula (1) (in the formula, X represents a chlorine atom or a bromine atom, and Y represents a hydrogen atom, a fluorine atom, a cyano group, an alkylcarbonyl group, a dialkylamino group, or an alkyl group which may be substituted with a fluorine atom) with acrylamide or acrylate ester in the presence of a metal catalyst and a reducing agent.
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