JAIN, RAJESH,VINAYAK, VIRENDER KUMAR,SHUKLA, NIDHI,AGGARWAL, NEERAJ,MEHTA, RAJAN
申请号：
EP10777464
公开号：
EP2432503A4
申请日:
2010.05.17
申请国别(地区):
EP
年份:
2013
代理人:
摘要：
The present invention relates to a novel influenza vaccine, a novel plasmid for preparing the same and a novel dosage form comprising the same. The present invention in particular relates to a recombinant modified vaccinia Ankara (MVA) virus comprising and capable of simultaneously expressing a cassette of at least four foreign genes from influenza virus, specifically an avian influenza virus, wherein the said genes are inserted at a non-essential site, within the MVA genome. The invention further relates to a recombinant modified vaccinia Ankara (MVA) virus comprising and capable of simultaneously expressing a cassette of not less than two foreign genes from influenza virus, wherein the said genes are inserted at a non-essential site, within the MVA genome, with the provision that at least one foreign gene is either PB2 or M2e. The invention also provides composition and methods of making the universal influenza vaccine.
